Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-b/Smad signalling
نویسندگان
چکیده
Diana Romero, Yoshiaki Kawano*, Nora Bengoa, Marjorie M. Walker, Nicole Maltry, Christof Niehrs, Jonathan Waxman and Robert Kypta Department of Surgery and Cancer, Imperial College London, London, W12 0NN, UK Cell Biology and Stem Cells Unit, CIC bioGUNE, Bilbao, Spain Centre for Pathology, Imperial College London, St Mary’s Hospital, London, W2 1NY, UK German Cancer Research Center, Heidelberg, 69120, Germany Institute of Molecular Biology, Mainz, 55128, Germany
منابع مشابه
Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling.
Loss of tissue organization is a hallmark of the early stages of cancer, and there is considerable interest in proteins that maintain normal tissue architecture. Prostate epithelial cells cultured in Matrigel form three-dimensional acini that mimic aspects of prostate gland development. The organization of these structures requires the tumor suppressor Dickkopf-3 (Dkk-3), a divergent member of ...
متن کاملDickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteases.
Dickkopf-3 (Dkk-3) is a secreted protein whose expression is downregulated in many types of cancer. Endogenous Dkk-3 is required for formation of acini in 3D cultures of prostate epithelial cells, where it inhibits transforming growth factor (TGF)-β/Smad signaling. Here, we examined the effects of Dkk-3 on the expression and activity of matrix metalloproteases (MMPs), which mediate the effects ...
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Transforming growth factor (TGF)-beta induces various cellular responses principally through Smad-dependent transcriptional regulation. Activated Smad complexes cooperate with transcription factors in regulating a group of target genes. The target genes controlled by the same Smad-cofactor complexes are denoted a synexpression group. We found that an Id-like helix-loop-helix protein, human homo...
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Members of the transforming growth factor-β (TGF-β) family of secreted proteins are present in all multicellular animals. TGF-β proteins are versatile intercellular signalling molecules that orchestrate cell fate decisions during development and maintain homeostasis in adults. The Smad family of signal transducers implements TGF-β signals in responsive cells. Given the ability of TGF-β ligands ...
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